Does ezetimibe modify clinical outcomes?
نویسندگان
چکیده
منابع مشابه
Ezetimibe: Clinical and Scientific Meaning of the IMPROVE-IT Study.
Ezetimibe: Clinical and scientific meaning of the IMPROVE-IT study After years of anxious wait, in June of the current year, the results of the clinical trial IMPROVE-IT were published in the New England Journal of Medicine.1 This was the first study to properly evaluate the clinical impact of adding ezetimibe to statin therapy. Until then, we had known that the combination of ezetimibe with st...
متن کاملThe IMPROVE-IT trial: current status and potential clinical implications of ezetimibe
ISSN 2041-6792 10.4155/CLI.10.14 © 2011 Future Science Ltd Reduction in low-density lipoprotein cholesterol (LDL-C) decreases the burden of coronary artery disease. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) improve cardiovascular disease outcomes by reduction of LDL-C and are currently considered first-line therapy for patients with hypercholesterolemia. Recent ev...
متن کاملClinical Efficacy and Safety of Ezetimibe on Major Cardiovascular Endpoints: Systematic Review and Meta-Analysis of Randomized Controlled Trials
BACKGROUND Randomized clinical trials (RCTs) about Ezetimibe's efficacy on patient-oriented outcomes have given discordant results. The aim of this study was to determine the net effect of Ezetimibe and of the widely marketed combination, Ezetimibe+simvastatin, on mortality and morbidity outcomes. METHODS AND FINDINGS We searched for RCT on Ezetimibe using MEDLINE, CCTR, EMBASE, ClinicalTrial...
متن کاملImpact of drug policy on regional trends in ezetimibe use.
BACKGROUND Ezetimibe use has steadily increased in Canada during the past decade even in the absence of evidence demonstrating a beneficial effect on clinical outcomes. Among the 4 most populated provinces in Canada, there is a gradient in the restrictiveness of ezetimibe in public-funded formularies (most to least strict: British Columbia, Alberta, Quebec, and Ontario). The effect of formulary...
متن کاملAnother clinical evidence straw on the $4 billion ezetimibe camel's back.
The clinical use of ezetimibe began in 2002 when the United tates Food and Drug Administration licensed the compound for he reduction of LDL-C either alone or in combination with a statin edication. Since then, clinical use of ezetimibe has grown to levls exceeding annual sales of $4 billion, in parallel with efforts to roadly market the drug to clinicians despite the absence of definiive data ...
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ورودعنوان ژورنال:
- Canadian family physician Medecin de famille canadien
دوره 61 3 شماره
صفحات -
تاریخ انتشار 2015